mavacamten will reduce the extent or influence of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Progestin and ethinyl estradiol are CYP3A4 substrates. Mavacamten may minimize systemic exposures of ethinyl estradiol and progestin, which may result in contraceptive failure or an increase in br… Read More